The effect of eight weeks of high-intensity interval training and moderate-intensity continuous training on some factors causing oxidative stress in the cardiomyocytes of mice with type II diabetes

Background and aims: Diabetic cardiomyopathy (DCM) is a major cause of morbidity mortality among diabetic patients. This study aimed to compare investigate the effects high-intensity interval training (HIIT) moderate-intensity continuous (MICT) on oxidative stress as one key links in development DCM mice with type 2 diabetes mellitus (T2DM). Methods: Forty male C57BL/6J were randomly assigned four groups equal number (Control, T2DM, T2DM+HIIT, T2DM+MICT). After induction HIIT MICT programs conducted 5 days week for 8 weeks. At end experimental period, blood heart samples collected subsequent measurements. Results: T2DM significantly up-regulated levels advanced glycation products (AGEs, P=0.001) expression 15-lipoxygenase (15-LOX, 4-hydroxy-2-nonenal (4-HNE, compared controlled mice. weeks training, increased insulin (P<0.001) while reducing fasting glucose (P<0.001, P=0.024, respectively). On other hand, it was found that decreased AGEs (P<0.001), 15-LOX (P=0.006, P=0.019, respectively), 4-HNE (P=0.008 P=0.035, Conclusion: Our findings revealed exercise particularly MICT, will be highly helpful prevention through improvement metabolism reduction expression.